Virtual Reality (VR) technology offers a safe and flexible environment for conducting operator training in different scenarios. For learning purposes, VR has proven to be highly efficient in comparison to conventional learning media for specific tasks. However, an adequate design of a natural user interface (NUI) is required, including accessibility, intuitive use and avoidance of distracting elements allowing the user to focus on the main task within the VR simulation. This paper presents a user study with the main focus on the comparison of two NUI instruction types: audio vs. text instruction in a process unknown to the prospective operator. The VR application is based upon a processing of insect larvae as fish feed from the operator’s perspective. To evaluate the instruction types, the participants were split into two equally sized groups, with one group conducting an audio version of the VR simulation, while the other group carried out the text version. After the experiment, user experience and user acceptance were evaluated by the participants in a survey. Furthermore, according to the Technology Acceptance Model, user behaviour and attitude towards the VR technology has been included in the study.